Sex, drugs, religion, and love are potent combinations in la zona, a regulated prostitution zone in the city of Reynosa, across the border from Hidalgo, Texas. During the years 2008 and 2009, a time of intense drug violence, Sarah Luna met and built relationships with two kinds of migrants, women who moved from rural Mexico to Reynosa to become sex workers and American missionaries who moved from the United States to forge a fellowship with those workers.

Luna examines the entanglements, both intimate and financial, that define their lives. Using the concept of obligar, she delves into the connections that tie sex workers to their families, their clients, their pimps, the missionaries, and the drug dealers—and to the guilt, power, and comfort of faith. Love in the Drug War scrutinizes not only la zona and the people who work to survive there, but also Reynosa itself—including the influences of the United States—adding nuance and new understanding to the current Mexico-US border crisis.